keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(-)-Cephaeline (dihydrochloride) is an enantiomer of Cephaeline. Cephaeline is a selective CYP2D6 inhibitor (IC50: 121 μM).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 594 | 5日内发货 | ||
100 mg | ¥ 7,410 | 8-10周 |
Cephaeline dihydrochloride 的其他形式现货产品:
产品描述 | (-)-Cephaeline (dihydrochloride) is an enantiomer of Cephaeline. Cephaeline is a selective CYP2D6 inhibitor (IC50: 121 μM). |
靶点活性 | CYP2D6:121 μM |
体外活性 | IC50 of Cephaeline against CYP2C9, CYP2D6, and CYP3A4 is over 1000, 121 and 1000 μM, respectively. Further experiments are performed to determine inhibition constants (Ki) for Cephaeline on the CYP2D6 and CYP3A4 activities Graphic analysis of Dixon plots at various Cephaeline concentrations for each of the two CYP enzyme assays yield Kis of 54 and 355 μM for CYP2D6 and CYP3A4, respectively. |
别名 | (-)-Cephaeline dihydrochloride, 盐酸吐根酚碱, NSC 32944 |
分子量 | 539.54 |
分子式 | C28H40Cl2N2O4 |
CAS No. | 5853-29-2 |
keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80mg/ml
H2O: 60mg/ml
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Cephaeline dihydrochloride 5853-29-2 Metabolism P450 NSC32944 (-)-Cephaeline dihydrochloride 盐酸吐根酚碱 Cephaeline Dihydrochloride NSC 32944 NSC-32944 Cephaeline Inhibitor inhibitor inhibit